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Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules

15 Aug 2025

Abstract excerpt

The organizational principles of nephronal segments are based on anatomical and physiological attributes that are linked to the homeostatic functions of the kidney. Recent molecular approaches have uncovered layers of deeper signatures and states in tubular cells that arise at various time points on the disease trajectory. Here, we introduce an analytical pipeline of multiplexed spatial protein imaging integrated...

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PMID: 40815665
DOI: 10.1126/sciadv.adv8918

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