Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zebrafish neurofibromatosis type 1 mutants show disruption of sleep but not of circadian rhythms.

Sleep - 11 Mar 2026

Lee Daniel A, Oikonomou Grigorios, Chiu Yun, Cho Alexis D, Xu Jin, Cammidge Tasha, Singh Chanpreet, Prober David A

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder that is associated with several developmental and behavioral phenotypes, including reduced and fragmented sleep at night. Here, we describe the role of NF1 in sleep in zebrafish, a diurnal vertebrate whose mechanisms of sleep control are broadly conserved with those of mammals. The zebrafish genome encodes two neurofibromin 1 (nf1) paralogs:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian Rhythm
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF1 gene

Share to Mutation

Share to Neurofibromatosis 1

Share to Neurofibromin 1

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 40801272
DOI: 10.1093/sleep/zsaf236
PMCID: PMC13016782

Genes

NF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish neurofibromatosis type 1 mutants show disruption of sleep but not of circadian rhythms.PMID 40801272Read ↗

Neurofibromatosis type 1 (Nf1)‐mutant mice exhibit increased sleep fragmentationSemantic proximity Read ↗

Melatonin is required for the circadian regulation of sleep.Semantic proximity Read ↗

The zebrafish mutant <i>dreammist</i> implicates sodium homeostasis in sleep regulationSemantic proximity Read ↗

Solving the mystery of human sleep schedules one mutation at a time.Semantic proximity Read ↗

Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of <i>night owl/LZTR1</i> and <i>NF1</i> in GABAergic sleep controlSemantic proximity Read ↗

A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.Semantic proximity Read ↗

Sleep disturbance as part of the neurofibromatosis type 1 phenotype in adults.Semantic proximity Read ↗

Sleep and Development in Genetically Tractable Model Organisms.Semantic proximity Read ↗

MBD5 haploinsufficiency is associated with sleep disturbance and disrupts circadian pathways common to Smith-Magenis and fragile X syndromes.Semantic proximity Read ↗

Usherin in the pineal gland: altered sleep in zebrafish models of Usher syndrome type 2aSemantic proximity Read ↗

Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating SleepSemantic proximity Read ↗

Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFkappaB Relish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.