An absent WD domain in the autophagy protein ATG16L1 leads to auditory and vestibular dysfunction and otoconial deficits in mice.

Abstract excerpt

OBJECTIVES: To examine the inner ear functions of mice that lack the WD domain (δWD) of autophagy protein ATG16L1. DESIGN: Mice were assessed with vestibular evoked potentials (VsEPs), auditory brainstem responses (ABRs) and four δWD mice were observed with electron microscopy to assess otolith otoconia loss, and cochlear hair cell loss. STUDY SAMPLE: Seven δWD mice and four control mice. RESULTS: Compared to...

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