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Article

Unravelling Osteoporosis: Key Genes and Potential Therapies.

Journal of cellular and molecular medicine - 1 Aug 2025

Fu Huichao, Wu Yunjiao, Lv Hongfei, Qiu Li-An, Hu Weifeng, Wu Hongyun, Qian Junda, Liang Xiongjie, Wang Xiaoyan, Xu Gongping

Abstract excerpt

Osteoporosis is a metabolic bone disease characterised by decreased bone mass and increased fracture risk, especially in aging women. Current treatments have limitations and side effects, prompting the need for novel therapeutic targets. Using Mendelian randomisation (MR) on the basis of GWAS data from the FinnGen consortium, we identified druggable genes associated with osteoporosis. Transcriptomic profiling,...

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Source

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Identifiers

PMID: 40764749
DOI: 10.1111/jcmm.70759
PMCID: PMC12325093

Genes

PSMA4
VEGFA
FMO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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