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PKA-driven SPP1 activation as a novel mechanism connecting the bone microenvironment to prostate cancer progression

2 Aug 2025

Abstract excerpt

Prostate cancer (PCa) bone metastasis (BM) poses a significant clinical challenge due to the heterogeneity of treatment responses and patient outcomes. In this study, we examined the role of Protein Kinase A (PKA) signaling in modulating the expression of osteopontin (SPP1/OPN), a protein associated with poor prognosis, within a subset of PCa BM patients. By integrating multi-omics results we identified a novel...

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PMID: 40753365
DOI: 10.1038/s41388-025-03511-z

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