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Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma

16 Jul 2025

Abstract excerpt

Purpose Programmed cell death (PCD) mechanisms play crucial roles in cancer progression and treatment response. This study aims to develop a PCD scores prediction model to evaluate the prognosis of hepatocellular carcinoma (HCC) and elucidate the tumor microenvironment differences. Methods We analyzed transcriptomic data from 363 HCC patients in the TCGA database and 221 patients in the GEO database to develop a...

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PMID: 40740783
DOI: 10.3389/fimmu.2025.1589563

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