Maternal PM2.5 Exposure and Cardiac Developmental Abnormalities in Fetuses and Neonates: Progressive Activation of the Complement and Coagulation Cascade

Abstract excerpt

Emerging studies indicate a positive correlation between maternal PM 2.5 exposure and an increased risk of congenital heart diseases (CHDs). However, the developmental origins in fetal and neonatal offspring, as well as the underlying mechanisms, remain elusive. To bridge this gap, we established an animal model of maternal PM 2.5 exposure and confirmed its adverse effects on cardiac function and structure in...