The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation.

doi:10.1007/s00018-025-05822-6

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Article

The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation.

Cellular and molecular life sciences : CMLS - 30 Jul 2025

Zhang Yuxin, Wang Tong-Yun, Yan Huihui, Guo Zhoule, Lian Zhonghao, Yao Hailan, Yuan Shuofeng, Ge Xing-Yi, Qiu Ye

Abstract excerpt

The prevalence of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important transition in the epidemic of coronavirus disease 2019 (COVID-19). Compared with other SARS-CoV-2 variants, Omicron and its subvariants exhibit decreased pathogenicity, thus contributing to the moderation of the epidemic. However, the mechanism underlying such changes is not fully understood. NSP5...

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Topics

Humans
SARS-CoV-2
Interferon-beta
COVID-19
Adaptor Proteins, Signal Transducing
Proteolysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

HEK293 Cells

Ubiquitination

Coronavirus 3C Proteases

Mutation

Virus Replication

Viral Nonstructural Proteins

Vero Cells

Animals

Source

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Identifiers

PMID: 40736574
DOI: 10.1007/s00018-025-05822-6
PMCID: PMC12311081

Genes

MAVS

Provenance

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