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Exploring the therapeutic mechanism of itraconazole combined with ritonavir on Candida albicans infection through network pharmacology and molecular docking

14 Jul 2025

Abstract excerpt

Background Autophagy induced by itraconazole and ritonavir was found involved in the pathogenesis of C. albicans. This study was designed to explore the possible molecular mechanism of itraconazole and ritonavir in the treatment of Candida albicans infection through autophagy pathway. Methods The overlapping targets of itraconazole and ritonavir, and those-related to C. albicans and autophagy were screened. Then...

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PMID: 40727105
DOI: 10.3389/fphar.2025.1578749

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