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Article

Geospatial inheritance across the breath of the RET mutational landscape of multiple endocrine neoplasia 2A.

Endocrine - 1 Nov 2025

Machens Andreas, Lorenz Kerstin, Weber Frank, Dralle Henning

Abstract excerpt

PURPOSE: This research, drawing on genealogical information gleaned over 40 years, aimed to clarify to what extent RET germline mutations causing multiple endocrine neoplasia 2A have been inherited. METHODS: Geospatial inheritance of 30 different RET germline mutations was explored by mapping gene carriers to the postal code area of residence and year of birth of the earliest affected common ancestor. RESULTS:...

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Identifiers

PMID: 40715712
DOI: 10.1007/s12020-025-04344-2

Genes

RET

Variants

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