Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium.

doi:10.1530/EJE-12-0919

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Article

Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium.

European journal of endocrinology - 1 Mar 2013

Machens Andreas, Lorenz Kerstin, Sekulla Carsten, Höppner Wolfgang, Frank-Raue Karin, Raue Friedhelm, Dralle Henning

Abstract excerpt

OBJECTIVE: Twenty years ago, the groundbreaking discovery that rearranged during transfection (RET) mutations underlie multiple endocrine neoplasia 2 (MEN2) and familial medullary thyroid cancer (FMTC) ushered in the era of personalized medicine. MEN2-associated signs, taking time to manifest, can be subtle. This study sought to clarify to what extent conventional estimates of 1:200 000-500 000 underestimate the...

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PMID: 23211574
DOI: 10.1530/EJE-12-0919

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