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Tumor Immune Microenvironment–Associated Prognostic and Mifamurtide-Response Gene Signatures for Localized Osteosarcoma: A Correlative Study of the ISG/OS-2 Trial

25 Jul 2025

Abstract excerpt

PURPOSE: A risk-adapted treatment strategy, the ISG/OS-2 trial, evaluated the use of mifamurtide in patients with P-glycoprotein (Pgp)-positive localized osteosarcoma. The primary objective was the identification of prognostic classifiers based on tumor microenvironment (TME) gene profiling in all patients and in those undergoing mifamurtide treatment. EXPERIMENTAL DESIGN: RNA from pretreatment formalin-fixed,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40711479
DOI: 10.1158/1078-0432.ccr-25-0649

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