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Comparative in vitro activities of eravacycline and tigecycline against carbapenem-resistant Acinetobacter baumannii: Insights from whole genome sequencing analysis.

Journal of global antimicrobial resistance - 1 Sept 2025

Zhong Yang, Teo Jocelyn Qi Min, Chang Hong Yi, Yeo Jiahao, Thong Shuhua, Tan Sihui, Yusoff Nurhayati Binte Monhamed, Lim Tze Peng, Kwa Andrea Lay Hoon

Abstract excerpt

OBJECTIVES: Eravacycline (ERV), a novel tetracycline-class antibiotic, has demonstrated efficacy against carbapenem-resistant Acinetobacter baumannii (CRAB) in Europe and the United States but has not been evaluated in Singapore. The objectives of this study are to evaluate the activity of ERV against CRAB clinical isolates from Singapore and to investigate the genetic profiles of these isolates, exploring novel...

Topics

Humans
Acinetobacter baumannii
Acinetobacter Infections
Carbapenems
Drug Resistance, Bacterial
Drug Resistance, Multiple
Genome, Bacterial
Mutation
Phylogeny

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tetracyclines

Tigecycline

Virulence Factors

Whole Genome Sequencing

Anti-Bacterial Agents

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Identifiers

PMID: 40706997
DOI: 10.1016/j.jgar.2025.06.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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