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In vivo evolution of tigecycline resistance in ST540 carbapenem-resistant Acinetobacter baumannii: Mechanisms and global epidemiological perspective.

International journal of antimicrobial agents - 1 Aug 2026

He Jintao, Zhang Hanqi, Liu Haiyang, Lin Wanxun, Liu Qianhao, Xu Qingye, Song Meijun, Chen Minhua, Liu Xiaochen, Tu Yuexing, Li Xi, Yu Yunsong, Zhou Hua, Hua Xiaoting, Yang Chuanxin

Abstract excerpt

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a persistent nosocomial pathogen, posing a major global health threat owing to limited treatment options. Although tigecycline is still effective against CRAB, resistance emergence has become a critical concern. This study aimed to elucidate the in vivo evolutionary mechanisms underlying tigecycline resistance in CRAB. A total of 11 STpas2-SToxf540 CRAB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42107728
DOI: 10.1016/j.ijantimicag.2026.107841

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