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Article

Driving a protective allele of the mosquito FREP1 gene to combat malaria.

Nature - 1 Sept 2025

Li Zhiqian, Dong Yuemei, You Lang, Corder Rodrigo M, Arzobal Jemariz, Yeun Audrey, Yang Lei, Marshall John M, Dimopoulos George, Bier Ethan

Abstract excerpt

Malaria remains a substantial global health challenge, causing approximately half a million deaths each year1. The mosquito fibrinogen-related protein 1 (FREP1) is required for malaria parasites to infect the midgut epithelium2. The naturally occurring FREP1Q allele has been reported to prevent parasite infection, while supporting essential physiological functions in the mosquito3. Here we generate congenic...

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Identifiers

PMID: 40702179
DOI: 10.1038/s41586-025-09283-6
PMCID: PMC12443604

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