Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma

20 Jul 2025

Abstract excerpt

Hepatitis B virus (HBV) integration is strongly associated with hepatocellular carcinoma (HCC). However, the genetic alterations and pathogenesis mechanisms remain significantly unexplored, especially for HBV-inserted cancer-related genes. This study identified recurrent HBV DNA integration into the CCDC91 gene in HCC tissues (n = 17) using pooled analysis and HBV capture sequencing. CCDC91 expression was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Hepatitis B Virus Studies
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40683971
DOI: 10.1038/s42003-025-08369-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinomaPMID 40683971Read ↗

HBV integrations reshaping genomic structures promote hepatocellular carcinomaSemantic proximity Read ↗

The function of targeted host genes determines the oncogenicity of HBV integration in hepatocellular carcinomaSemantic proximity Read ↗

Analysis of viral integration reveals new insights of oncogenic mechanism in HBV infected- intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinomaSemantic proximity Read ↗

Comprehensive characterization of viral integrations and genomic aberrations in HBV‐infected intrahepatic cholangiocarcinomasSemantic proximity Read ↗

Recurrent Targeted Genes of Hepatitis B Virus in the Liver Cancer Genomes Identified by a Next-Generation Sequencing–Based ApproachSemantic proximity Read ↗

Long read sequencing reveals sequential complex rearrangements driven by Hepatitis B virus integrationSemantic proximity Read ↗

Characteristics of Hepatitis B virus integration and mechanism of inducing chromosome translocationSemantic proximity Read ↗

The fusion landscape of hepatocellular carcinomaSemantic proximity Read ↗

Genomic and oncogenic preference of HBV integration in hepatocellular carcinomaSemantic proximity Read ↗

The landscape of gene fusions in hepatocellular carcinomaSemantic proximity Read ↗

Insights into Hepatitis B Virus DNA Integration-55 Years after Virus DiscoverySemantic proximity Read ↗

Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.