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Peptidomic analysis of CSF reveals new biomarker candidates for amyotrophic lateral sclerosis

18 Jul 2025

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, and novel biomarkers are needed. We applied mass-spectrometry-based peptidomic analysis in cerebrospinal fluid (CSF) samples of ALS and non-neurodegenerative control patients (Con) from a discovery (n = 48) and validation (n = 109) cohort for biomarker discovery. Systematic selection revealed a panel of eight novel peptide biomarker...

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PMID: 40681694
DOI: 10.1038/s44321-025-00272-w

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