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Article

Ellagic acid mediated pyroptosis in hepatocellular carcinoma via the ESR1/G6PD pathway

16 Jul 2025

Abstract excerpt

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related morbidity and mortality worldwide. Ellagic acid (EA), a natural polyphenol, has demonstrated antitumor properties, but its precise mechanisms in HCC remain unclear. Here, we mainly explored the pathway of ellagic acid-mediated HCC cell pyroptosis in xenograft nude mice models and two cell lines using flow cytometry, oxidative stress kits,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40680865
DOI: 10.1016/j.bcp.2025.117178

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