Article
Longer scans boost prediction and cut costs in brain-wide association studies.
Nature - 1 Aug 2025
Ooi Leon Qi Rong, Orban Csaba, Zhang Shaoshi, Nichols Thomas E, Tan Trevor Wei Kiat, Kong Ru, Marek Scott, Dosenbach Nico U F, Laumann Timothy O, Gordon Evan M, Yap Kwong Hsia, Ji Fang, Chong Joanna Su Xian, Chen Christopher, An Lijun, Franzmeier Nicolai, Roemer-Cassiano Sebastian N, Hu Qingyu, Ren Jianxun, Liu Hesheng, Chopra Sidhant, Cocuzza Carrisa V, Baker Justin T, Zhou Juan Helen, Bzdok Danilo, Eickhoff Simon B, Holmes Avram J, Yeo B T Thomas
Abstract excerpt
A pervasive dilemma in brain-wide association studies1 (BWAS) is whether to prioritize functional magnetic resonance imaging (fMRI) scan time or sample size. We derive a theoretical model showing that individual-level phenotypic prediction accuracy increases with sample size and total scan duration (sample size × scan time per participant). The model explains empirical prediction accuracies well across 76...
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