Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The proteostatic landscape of healthy human oocytes

16 Jul 2025

Abstract excerpt

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis (proteostasis) within these cells. However, the mechanisms of proteostasis in human oocytes remain virtually unstudied. We present the first large-scale study of proteostatic activity in human oocytes using over 100 freshly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian function and disorders
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40670770
DOI: 10.1038/s44318-025-00493-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The proteostatic landscape of healthy human oocytesPMID 40670770Read ↗

Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytesSemantic proximity Read ↗

The maintenance of oocytes in the mammalian ovary involves extreme protein longevitySemantic proximity Read ↗

Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive HealthSemantic proximity Read ↗

“All-in-one” Single-Cell Proteomic Analysis of Protein Alterations in Human Oocytes Undergoing in Vitro AgingSemantic proximity Read ↗

Autophagy in Female Fertility: A Role in Oxidative Stress and AgingSemantic proximity Read ↗

Control of mitochondrial integrity influences oocyte quality during reproductive agingSemantic proximity Read ↗

A proteomic signature of oocyte quality from models of varying oocyte developmental competenceSemantic proximity Read ↗

Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian AgingSemantic proximity Read ↗

Interplay of Oxidative Stress, Autophagy, and Rubicon in Ovarian Follicle Dynamics: Orchestrating Ovarian AgingSemantic proximity Read ↗

The role of mitophagy during oocyte aging in human, mouse, and Drosophila: implications for oocyte quality and mitochondrial diseaseSemantic proximity Read ↗

Mitochondria: Their relevance during oocyte ageingSemantic proximity Read ↗

The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammalsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.