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Small RNA in sperm–Paternal contributions to human embryo development

17 Jul 2025

Abstract excerpt

Sperm not only delivers the paternal genome to the oocyte but also regulatory small RNA (sRNA). However, the role of sRNA in fertilisation and human embryo development remains poorly understood. Here, couples undergoing IVF are recruited, and sperm sRNA analysed to investigate their role in IVF treatment. Differential expression of mitochondrial sRNA and Y-RNA are observed in relation to sperm concentration. For...

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PMID: 40670377
DOI: 10.1038/s41467-025-62015-2

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