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Article

A high-throughput screening method for selecting feature SNPs to evaluate breed diversity and infer ancestry.

Genome research - 1 Aug 2025

Zhang Meilin, Du Heng, Zhang Yu, Zhuo Yue, Liu Zhen, Xue Yahui, Zhou Lei, Zhou Sixuan, Li Wanying, Liu Jian-Feng

Abstract excerpt

As the scale of deep whole-genome sequencing (WGS) data has grown exponentially, hundreds of millions of single nucleotide polymorphisms (SNPs) have been identified in livestock. Utilizing these massive SNP data in population stratification analysis, ancestry prediction, and breed diversity assessments leads to overfitting issues in computational models and creates computational bottlenecks. Therefore, selecting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40664476
DOI: 10.1101/gr.280176.124
PMCID: PMC12315865

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