Article
Large-scale selection of highly informative microhaplotypes for ancestry inference and population specific informativeness.
Forensic science international. Genetics - 1 Jan 2025
de Barros Rodrigues Maria Luisa, Rodrigues Marcelo Porto, Norton Heather L, Mendes-Junior Celso Teixeira, Simões Aguinaldo Luiz, Lawson Daniel John
Abstract excerpt
Microhaplotypes (MHs) describe physically close genetic markers that are inherited together and are gaining prominence due to their efficiency in forensic, clinical, and population studies. They excel in kinship analysis, DNA mixture detection, and ancestry inference, offering advantages in precision over individual SNPs and STRs. In this study, a pipeline was developed to efficiently select highly informative...
Topics
- Humans
- Genetics, Population
- Polymorphism, Single Nucleotide
- Haplotypes
- Genetic Markers
- DNA Fingerprinting
- Brazil
- Racial Groups