Generating synthetic genotypes using diffusion models.

Abstract excerpt

SUMMARY: In this paper, we introduce the first diffusion model designed to generate complete synthetic human genotypes, which, by standard protocols, one can straightforwardly expand into full-length, DNA-level genomes. The synthetic genotypes mimic real human genotypes without just reproducing known genotypes, in terms of approved metrics. When training biomedically relevant classifiers with synthetic genotypes,...

Topics

• Humans
• Genotype
• Models, Genetic
• Genome, Human
• Algorithms
• Genome-Wide Association Study