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Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice.

Cell calcium - 1 Sept 2025

Lin Yuan, Bai Yang, Martin-Avila Alejandro, Li Wei, Wu Xujun, Ziff Edward, Gan Wen-Biao

Abstract excerpt

INTRODUCTION: Presenilin (PS) gene mutations cause memory impairment in early-onset familial Alzheimer's disease (FAD), but the underlying mechanisms remain unclear. METHODS: We examined the effects of the PS1 M146V FAD mutation on motor learning, motor learning-related changes in neuronal Ca2+activity and CREB phosphorylation in the primary motor cortex. RESULTS: We found that PS1 M146V knock-in mice displayed...

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Identifiers

PMID: 40609403
DOI: 10.1016/j.ceca.2025.103048
PMCID: PMC12374543

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