Pan-cancer copy number analysis identifies optimized size thresholds and co-occurrence models for individualized risk stratification

Abstract excerpt

Chromosome instability leading to aneuploidy and accumulation of copy number gains or losses is a hallmark of cancer. Copy number alteration (CNA) signatures are increasingly used for cancer risk stratification, but size thresholds for defining CNAs across cancers are variable and the biological and clinical implications of CNA size heterogeneity and co-occurrence are incompletely understood. Here we analyze CNA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromatin Remodeling and Cancer
• Share to Glioma Diagnosis and Treatment
• Share to Meningioma and schwannoma management