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Viral and non-viral vectors in gene therapy: current state and clinical perspectives

2 Jul 2025

Abstract excerpt

Advancements in gene therapy have achieved significant milestones in treating human diseases, offering renewed hope to patients with limited options. Key to this progress are vectors, which include both viral and non-viral methodologies that impact the success of gene therapy. Over the past two decades, three widely used viral vectors-lentiviruses (LV), adenoviruses (Ad), and adeno-associated viruses (AAV)-have...

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PMID: 40602323
DOI: 10.1016/j.ebiom.2025.105834

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