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Article

Evolutionary dynamics in the genome of ocular Chlamydia trachomatis strains from Northern Tanzania following mass drug administration.

Microbial genomics - 1 Jul 2025

Ghasemian Ehsan, Ramadhani Athumani, Harte Anna, Mafuru Elias, Derrick Tamsyn, Mtuy Tara, Massae Patrick, Malissa Aiweda, Breuer Judith, Pickering Harry, Bailey Robin L, Mabey David, Burton Matthew J, Holland Martin J

Abstract excerpt

Trachoma, caused by Chlamydia trachomatis (Ct), remains a leading cause of preventable infection-induced blindness worldwide. We conducted a 4-year longitudinal study in three trachoma-endemic villages in Northern Tanzania, tracking infection dynamics and factors influencing trachomatous scarring progression and persistence pre- and post-mass drug administration (MDA) interventions. We analysed 118 whole genomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40601472
DOI: 10.1099/mgen.0.001431
PMCID: PMC12222737

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