Article
Population-based analysis of ocular Chlamydia trachomatis in trachoma-endemic West African communities identifies genomic markers of disease severity.
Genome medicine - 26 Feb 2018
Last A R, Pickering H, Roberts C H, Coll F, Phelan J, Burr S E, Cassama E, Nabicassa M, Seth-Smith H M B, Hadfield J, Cutcliffe L T, Clarke I N, Mabey D C W, Bailey R L, Clark T G, Thomson N R, Holland M J
Abstract excerpt
BACKGROUND: Chlamydia trachomatis (Ct) is the most common infectious cause of blindness and bacterial sexually transmitted infection worldwide. Ct strain-specific differences in clinical trachoma suggest that genetic polymorphisms in Ct may contribute to the observed variability in severity of clinical disease. METHODS: Using Ct whole genome sequences obtained directly from conjunctival swabs, we studied Ct...
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