Article
Transposon insertion causes ctnnb2 transcript instability that results in the maternal effect zebrafish ichabod (ich) mutation.
Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Sept 2025
Varga Zsombor, Kagan Ferenc, Maegawa Shingo, Nagy Ágnes, Okendo Javan, Burgess Shawn M, Weinberg Eric S, Varga Máté
Abstract excerpt
The maternal-effect mutation ichabod (ich) results in ventralized zebrafish embryos due to impaired induction of the dorsal canonical Wnt-signaling pathway. While previous studies linked the phenotype to reduced ctnnb2 transcript levels, the causative mutation remained unidentified. Using long-read sequencing, we discovered that the ich phenotype stems from the insertion of a non-autonomous...
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