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Resolving the APN controversy in PEDV infection: Comparative kinetic characterization through single-virus tracking

30 Jun 2025

Abstract excerpt

Aminopeptidase N (APN) plays multiple roles in various physiological processes, with its function as a viral receptor in several coronaviruses being one of the most prominent. However, the role of porcine APN (pAPN) in porcine epidemic diarrhea virus (PEDV) has remained controversial. Single-virus tracking enables a more comprehensive dynamic dissection of pAPN utilization during virus entry. In this study, a...

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PMID: 40587580
DOI: 10.1371/journal.ppat.1013317

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