Whole-genome phenotype prediction with machine learning: open problems in bacterial genomics.

Abstract excerpt

MOTIVATION: How can we identify causal genetic mechanisms governing bacterial traits? Initial efforts entrusting machine learning models to handle the task of predicting phenotype from genotype yield high accuracy scores. However, attempts to extract meaningful interpretations from the predictive models are found to be corrupted by falsely identified 'causal' features. Relying solely on pattern recognition and...

Topics

• Machine Learning
• Genome, Bacterial
• Phenotype
• Genomics
• Genotype
• Staphylococcus aureus
• Bacteria