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Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney

27 Jun 2025

Abstract excerpt

INTRODUCTION: The hepatitis E virus (HEV; species Paslahepevirus balayani) is a common human pathogenic and zoonotic virus that can cause both acute fulminant and chronic hepatitis. Despite its reputation as a hepatotropic virus, HEV infection is also associated with a number of extrahepatic diseases, including kidney disorders. However, the extent to which HEV replicates in kidney cells remains unclear. The...

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PMID: 40575997
DOI: 10.1111/liv.70183

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