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Article

Two clinical subgroups of immune checkpoint inhibitor-induced inflammatory arthritis determined by latent class analysis.

Seminars in arthritis and rheumatism - 1 Oct 2025

Cappelli Laura C, Perin Jamie, Zeger Scott, Jones Michelle, Bingham Clifton O, Shah Ami A

Abstract excerpt

BACKGROUND: Immune checkpoint inhibitors (ICI) for cancer treatment can cause inflammatory arthritis (IA). Since ICI-IA has a unique pathogenesis, applying categories of traditional IA may be of limited use. METHODS: Participants were ≥18 years old, treated with anti-PD-1, anti-PD-L1, and/or anti-CTLA-4 agents, and had ICI-IA diagnosed by a rheumatologist. We clustered patients using latent class analysis (LCA)...

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Identifiers

PMID: 40540778
DOI: 10.1016/j.semarthrit.2025.152773
PMCID: PMC12281293

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