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H3K36me3‐Guided m 6 A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

19 Jun 2025

Abstract excerpt

Abstract Hepatocellular carcinoma (HCC) is one of the most lethal malignancies and epigenetic modifiers play a key role in HCC progression. Histone H3 trimethylation at lysine‐36 (H3K36me3) determines deposition of mRNA de novo N 6 ‐methyladenosine (m 6 A) modification. However, it remains largely elusive how long noncoding RNAs (lncRNAs) are selected for proper m 6 A methylation. The current study provides...

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PMID: 40536332
DOI: 10.1002/advs.202414909

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