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Article

Molecular phenotypic linkage between N6-methyladenosine methylation and tumor immune microenvironment in hepatocellular carcinoma.

Journal of cancer research and clinical oncology - 1 Aug 2023

Zhang Feng, Bi Junming, Liao Jiasheng, Zhong Wenhui, Yu Min, Lu Xin, Che Jinhui, Chen Zhiyuan, Xu Haobin, Hu Shixiong, Liu Yubin, Guo Shuijiao

Abstract excerpt

PURPOSE: The crucial role of N6-methyladenosine (m6A) methylation in anti-tumor immunity and immunotherapy has been broadly depicted. However, the molecular phenotypic linkages between m6A modification pattern and immunological ecosystem are expected to be disentangled in hepatocellular carcinoma (HCC), for immunotherapeutic unresponsiveness circumvention and combination with promising drug agents. METHODS:...

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PMID: 36826593
DOI: 10.1007/s00432-023-04589-2

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