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Article

Application of clinical exome sequencing in sperm donor screening in China.

Journal of assisted reproduction and genetics - 1 Jul 2025

Huang Jie, Yu Man, Yang Jie, Xue Wenjing, Zhang Zhou, Shi Juanzi, Shi Wenhao

Abstract excerpt

PURPOSE: In China, genetic testing is conducted by only a small proportion of sperm banks. Traditional sperm donor screening primarily relies on family history to exclude individuals with known genetic diseases. However, this method does not fully address the genetic risks associated with recessive and late-onset dominant disorders. This study aims to conduct genetic testing for sperm donors using high-coverage...

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Identifiers

PMID: 40500584
DOI: 10.1007/s10815-025-03540-3
PMCID: PMC12356805

Genes

FLG
GJB2
SMN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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