Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Upadacitinib for refractory Behçet’s disease with myelodysplastic syndrome and trisomy 8/9: a case report and mechanistic insights

27 May 2025

Abstract excerpt

Background: Behçet's disease (BD), a multisystemic inflammatory disorder with genetic predisposition, is frequently complicated by myelodysplastic syndrome (MDS), particularly in cases harboring trisomy 8. Patients with refractory BD-MDS exhibit poor responses to conventional therapies, including glucocorticoids and TNF-α inhibitors, underscoring the need for novel therapeutic strategies. Janus kinase (JAK)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to Ocular Diseases and Behçet’s Syndrome
Share to Otitis Media and Relapsing Polychondritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40496858
DOI: 10.3389/fimmu.2025.1609884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Upadacitinib for refractory Behçet’s disease with myelodysplastic syndrome and trisomy 8/9: a case report and mechanistic insightsPMID 40496858Read ↗

Clinical features and novel pathogenic variants of patients with Behçet’s disease like trisomy 8Semantic proximity Read ↗

Behçet's syndrome-like features revealing myelodysplastic syndrome with TP53 mutation: a case report.Semantic proximity Read ↗

Autoinflammatory syndromes mimicking Behçet's disease with gastrointestinal involvement: a retrospective analysis.Semantic proximity Read ↗

High Incidence of Gastrointestinal Ulceration and Cytogenetic Aberration of Trisomy 8 as Typical Features of Behçet’s Disease Associated with Myelodysplastic Syndrome: A Series of 16 Consecutive Chinese Patients from the Shanghai Behçet’s Disease Database and Comparison with the LiteratureSemantic proximity Read ↗

A reappraisal of the association between Behçet's disease, myelodysplastic syndrome and the presence of trisomy 8: a systematic literature review.Semantic proximity Read ↗

Upadacitinib: Mechanism of action, clinical, and translational scienceSemantic proximity Read ↗

Primary CD34 <sup>+</sup> cells of patients with VEXAS syndrome are highly sensitive to targeted treatment with TAK-243 and pevonedistatSemantic proximity Read ↗

A Novel Subtype of Myeloproliferative Neoplasms Driven by a MYC-Alarmin AxisSemantic proximity Read ↗

Clinical characteristics and treatment of “cytopenia phenotype” in Behçet syndrome: A Retrospective Cohort Study using a large data set from a referral center in ChinaSemantic proximity Read ↗

Current pharmacological solutions for Behçet's syndrome.Semantic proximity Read ↗

Clinical features and prognosis of patients with gastrointestinal Behçet's disease-like syndrome and myelodysplastic syndrome with and without trisomy 8Semantic proximity Read ↗

Potential benefits of JAK inhibitor therapy in Blau syndrome: a case report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.