Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultraviolet radiation induces caspase cleavage and nuclear translocation of heme oxygenase 1 (HO-1) to activate autophagy in skin keratinocytes.

The FEBS journal - 1 Oct 2025

Bian Chunxiang, Wu Yan, Zhang Mingwang, Ge Lan, Zhong Maojiao, Zheng Chunling, Chen Long, Lei Mingxing, Nisar Muhammad Farrukh, Pourzand Charareh, Bartsch Jörg W, Zhong Julia Li, Wang Mei

Abstract excerpt

The skin is vulnerable to ultraviolet (UV) exposure, and as a repair mechanism, autophagy activation is essential to eliminate UV-damaged skin cells to maintain tissue homeostasis. As a UV-induced protein, heme oxygenase-1 (HO-1; 32 kDa) is implicated in protecting cells from oxidative stress and plays an important role in disease prevention. However, the mechanism of photoprotection in skin cells has yet to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to ARNTL Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy

Share to Caspase 1

Share to Heme Oxygenase-1

Share to Keratinocytes

Share to Molecular Weight

Share to Proteolysis

Source

Identifiers

PMID: 40488590
DOI: 10.1111/febs.70144

Genes

CASP1
ARNT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultraviolet radiation induces caspase cleavage and nuclear translocation of heme oxygenase 1 (HO-1) to activate autophagy in skin keratinocytes.PMID 40488590Read ↗

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based PhototherapySemantic proximity Read ↗

Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven PhotoagingSemantic proximity Read ↗

A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytesSemantic proximity Read ↗

The role of Bach1 in ultraviolet A-mediated human heme oxygenase 1 regulation in human skin fibroblastsSemantic proximity Read ↗

Photoaging of human skinSemantic proximity Read ↗

Molecular aspects of ultraviolet radiation-induced apoptosis in the skin.Semantic proximity Read ↗

A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivitySemantic proximity Read ↗

ATG5-mediated keratinocyte ferroptosis promotes M1 polarization of macrophages to aggravate UVB-induced skin inflammationSemantic proximity Read ↗

Collagen type III resists UVB induced photoaging of HaCaT cells by regulating mTOR signaling pathwaySemantic proximity Read ↗

Ultraviolet‐B Irradiation and Matrix MetalloproteinasesSemantic proximity Read ↗

Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiationSemantic proximity Read ↗

MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.