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Article

The role of Bach1 in ultraviolet A-mediated human heme oxygenase 1 regulation in human skin fibroblasts

8 Nov 2011

Abstract excerpt

Up-regulation of heme oxygenase 1 (HO-1) by ultraviolet A (UVA; 320-380 nm) irradiation of human skin cells protects them against oxidative stress. The role of Nrf2 in up-regulation of HO-1 and other phase II genes is well established. The mechanism underlying Bach1-mediated HO-1 repression is less well understood although cellular localization seems to be crucial. Because prolonged HO-1 overexpression is likely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22107958
DOI: 10.1016/j.freeradbiomed.2011.10.494

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