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Article

Nonlinearity and sex differences in the performance of a polygenic risk score for juvenile idiopathic arthritis

22 May 2025

Abstract excerpt

Background: Juvenile idiopathic arthritis (JIA) is an immune-mediated pediatric disease believed to result from a complex interplay of genetic and environmental factors. Genome-wide association studies have enabled calculation of polygenic risk scores (PRS) for JIA. Understanding how the PRS associates with JIA and whether it performs similarly across sexes is essential for its utility in future studies. Methods:...

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PMID: 40486524
DOI: 10.3389/fimmu.2025.1531390

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