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Insights into the E2F target genes in breast cancer: associations of pathway genes with prognosis and immune cell filtration based on in silico and ex vivo analyses

6 Jun 2025

Abstract excerpt

BACKGROUND: E2F transcription factors are crucial in various biological processes, including cell proliferation, differentiation, and apoptosis. However, the exact role of E2F target genes in breast cancer (BC), as well as their influence on survival and immune response, remains poorly understood. METHODS: To investigate the differential expression of E2F target genes and their relationship with patient prognosis...

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PMID: 40481544
DOI: 10.1186/s12935-025-03839-2

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