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The pyroptosis-related gene signature predicts prognosis and reveals immune microenvironment infiltration in reclassified glioblastoma based on 2021 WHO classification

21 Jul 2025

Abstract excerpt

Background: Glioblastoma (GBM) is a highly malignant brain tumor with a poor prognosis. The WHO Classification of Tumors of the Central Nervous System (WHO CNS5) reclassified GBM in 2021. Pyroptosis, as an inflammatory form of programmed cell death, could regulate tumor cell proliferation, invasion, and metastasis. However, the role of pyroptosis in the newly defined GBM and its correlation with immunity have not...

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PMID: 40761791
DOI: 10.3389/fimmu.2025.1617036

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