Article
Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer.
Journal for immunotherapy of cancer - 3 Jun 2025
Volkmar Michael, Hoser Dana, Lauenstein Claudia, Rebmann Janina, Hotz-Wagenblatt Agnes, Rieger Jan, Poschke Isabel, Becker Jonas P, Riemer Angelika B, Sprick Martin, Trumpp Andreas, Strobel Oliver, Blankenstein Thomas, Willimsky Gerald, Offringa Rienk
Abstract excerpt
BACKGROUND: Personalized immunotherapy of pancreatic ductal adenocarcinoma (PDAC) through T-cell mediated targeting of tumor-specific, mutanome-encoded neoepitopes may offer new opportunities to combat this disease, in particular by countering recurrence after primary tumor resection. However, the sensitive and accurate calling of somatic mutations in PDAC tissue samples is compromised by the low tumor cell...
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