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Article

SFTSV NSs degrades SAFA via autophagy to suppress SAFA-dependent antiviral response

3 Jun 2025

Abstract excerpt

Severe fever with thrombocytopenia syndrome virus (SFTSV), a tick-borne bunyavirus, causes an emerging viral hemorrhagic fever with a high mortality rate. SFTSV nonstructural protein S (NSs) is a virulence factor that sequesters antiviral proteins into autophagic vesicles for degradation to escape host immune response. SAFA (Nuclear scaffold attachment factor A), an RNA sensor, recognizes viral RNA and is...

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PMID: 40460159
DOI: 10.1371/journal.ppat.1013201

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