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Mechanisms and therapeutic potential of disulphidptosis in cancer

1 Oct 2024

Abstract excerpt

SLC7A11 plays a pivotal role in tumour development by facilitating cystine import to enhance glutathione synthesis and counteract oxidative stress. Disulphidptosis, an emerging form of cell death observed in cells with high expression of SLC7A11 under glucose deprivation, is regulated through reduction-oxidation reactions and disulphide bond formation. This process leads to contraction and collapse of the F-actin...

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PMID: 39354653
DOI: 10.1111/cpr.13752

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