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Article

Human microbiota influence the immune cell composition and gene expression in the tumor environment of a murine model of glioma

30 May 2025

Abstract excerpt

BACKGROUND: Immunotherapy has shown success against other cancers but not glioblastoma. Previous data has revealed that microbiota influences anti-PD-1 efficacy. We have previously found that, when using gnotobiotic mice transplanted with human fecal microbiota, the gut microbial composition influenced the response to anti-PD-1 in a mouse model of glioma. However, the role of the human microbiota in influencing...

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PMID: 40443227
DOI: 10.1080/19490976.2025.2508432

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