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Article

Cleavage of the Meckel-Gruber syndrome protein TMEM67 by ADAMTS9 uncouples Wnt signaling and ciliogenesis.

Nature communications - 28 May 2025

Ahmed Manu, Fischer Sydney, Robert Karyn L, Lange Karen I, Stuck Michael W, Best Sunayna, Johnson Colin A, Pazour Gregory J, Blacque Oliver E, Nandadasa Sumeda

Abstract excerpt

TMEM67 mutations cause Meckel-Gruber syndrome and other related ciliopathies. TMEM67 is involved in both ciliary transition zone assembly, and non-canonical Wnt signaling mediated by its extracellular domain. How TMEM67 performs these two separate functions is not known. We identify a cleavage motif in the extracellular domain of TMEM67 cleaved by the extracellular matrix metalloproteinase ADAMTS9. This cleavage...

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Source

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Identifiers

PMID: 40436881
DOI: 10.1038/s41467-025-60294-3
PMCID: PMC12119803

Genes

TMEM67
ADAMTS9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Cleavage of the Meckel-Gruber syndrome protein TMEM67 by ADAMTS9 uncouples Wnt signaling and ciliogenesis.PMID 40436881Read ↗

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