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Construction of Minigenome Replicon of Nipah Virus and Investigation of Biological Activity

15 May 2025

Abstract excerpt

Nipah virus (NiV), a highly lethal zoonotic pathogen causing encephalitis and respiratory diseases with mortality rates up to 40–70%, faces research limitations due to its strict biosafety level 4 (BSL-4) containment requirements, hindering antiviral development. To address this, we generated two NiV minigenome replicons (Fluc- and EGFP-based) expressed via helper plasmids encoding viral N, P, and L proteins,...

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PMID: 40431718
DOI: 10.3390/v17050707

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