Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative Analysis of 5-ALA and Fluorescent Techniques in High-Grade Glioma Treatment

10 May 2025

Abstract excerpt

Background: 5-Aminolevulinic acid (5-ALA) serves as a precursor in the heme biosynthesis pathway, resulting in the selective accumulation of protoporphyrin IX (PpIX) within glioma cells. This property facilitates fluorescence-guided resection (FGR) in high-grade gliomas (HGGs), enhancing surgical precision and oncological results. Nonetheless, its clinical implementation is restricted by factors such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthesia and Neurotoxicity Research
Share to Glioma Diagnosis and Treatment
Share to Nanoplatforms for cancer theranostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40426988
DOI: 10.3390/biomedicines13051161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative Analysis of 5-ALA and Fluorescent Techniques in High-Grade Glioma TreatmentPMID 40426988Read ↗

Localization of protoporphyrin IX in glioma patients with paired stimulated Raman histology and two-photon excitation fluorescence microscopySemantic proximity Read ↗

Systematic review of photodynamic therapy in gliomasSemantic proximity Read ↗

Intra-operative 5-aminolevulinic acid (ALA)-induced fluorescence of medulloblastoma: phenotypic variability and CD133(+) expression according to different fluorescence patterns.Semantic proximity Read ↗

A Data-Driven Approach to Predicting 5-Aminolevulinic Acid-Induced Fluorescence and World Health Organization Grade in Newly Diagnosed Diffuse Gliomas.Semantic proximity Read ↗

Molecular Characteristic of High Grade Glioma in Relation to 5-ala Fluorescence IntensitySemantic proximity Read ↗

Radiodynamic Therapy for High-Grade Glioma in Normoxic and Hypoxic Environments for High-Grade GliomaSemantic proximity Read ↗

Genetically Determined Syndromes Associated with an Increased Risk of Glioma – the Use of Photodynamic Therapy (PDT)Semantic proximity Read ↗

In order for the light to shine so brightly, the darkness must be present—why do cancers fluoresce with 5-aminolaevulinic acid?Semantic proximity Read ↗

5-Aminolevulinic acid-mediated photodynamic therapy can target human glioma stem-like cells refractory to antineoplastic agentsSemantic proximity Read ↗

Intraoperative detection of IDH-mutant glioma using fluorescence lifetime imaging.Semantic proximity Read ↗

A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumorsSemantic proximity Read ↗

Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic NanovesiclesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.